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References

LAM Week

References

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  12. Moir, L. M. et al. Doxycycline inhibits MMP-2 secretion from TSC2-null MEFs and lymphangioleiomyomatosis cells. Br. J. Pharmacol. 164, 83-92, doi:10.1111/j.1476-5381.2011.01344.x (2011).

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  32. Goncharova, E., Goncharov, D., Noonan, D. & Krymskaya, V. P. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J. Cell Biol. 167, 1171-1182 (2004).

  33. Goncharova, E. A. et al. mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells. Mol. Cell. Biol. 31, 2484-2498, doi:10.1128/mcb.01061-10 (2011).

  34. El-Hashemite, N. & Kwiatkowski, D. J. Interferon-g-Jak-Stat Signaling in Pulmonary Lymphangioleiomyomatosis and Renal Angiomyolipoma: A Potential Therapeutic Target. Am. J. Respir. Cell Mol. Biol. 33, 227-230 (2005).

  35. El-Hashemite, N., Zhang, H., Walker, V., Hoffmeister, K. M. & Kwiatkowski, D. J. Perturbed IFN-g-Jak-Signal Transducers and Activators of Transcription Signaling in Tuberous Sclerosis Mouse Models: Synergistic Effects of Rapamycin-IFN-g Treatment. Cancer Res 64, 3436-3443 (2004).

  36. Goncharova, E. A. et al. Interferon b Augments Tuberous Sclerosis Complex 2 (TSC2)-Dependent Inhibition of TSC2-Null ELT3 and Human Lymphangioleiomyomatosis-Derived Cell Proliferation. Mol Pharmacol 73, 778-788, doi:10.1124/mol.107.040824 (2008).

  37. Goncharova, E. A. et al. Signal Transducer and Activator of Transcription 3 Is Required for Abnormal Proliferation and Survival of TSC2-Deficient Cells: Relevance to Pulmonary Lymphangioleiomyomatosis. Mol Pharmacol 76, 766-777 (2009).

  38. Parkhitko, A. et al. Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proceedings of the National Academy of Sciences 108, 12455-12460, doi:10.1073/pnas.1104361108 (2011).

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  48. Young, L. R. et al. Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. Lancet 1,445-452 (2013).

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  50. Karnezis, T. et al. VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium. Canc. Cell 21, 181-195, doi:http://dx.doi.org/10.1016/j.ccr.2011.12.026 (2012).

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  52. Davis, J. M. et al. Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells. Journal of Histochemistry & Cytochemistry 61, 580-590, doi:10.1369/0022155413489311 (2013).

  53. Baldwin, M. E. et al. The Specificity of Receptor Binding by Vascular Endothelial Growth Factor-D Is Different in Mouse and Man. J. Biol. Chem. 276, 19166-19171, doi:10.1074/jbc.M100097200 (2001).

  54. Baldwin, M. E. et al. Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System. Mol. Cell. Biol. 25, 2441-2449, doi:10.1128/mcb.25.6.2441-2449.2005 (2005).