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ATS Pediatric Pulmonary Reading List
Reading List

Mission Statement

The mission of the ATS training committee's pediatric pulmonary training list is to provide pediatric pulmonary trainees and pediatric residents with a list of peer-reviewed articles that cover key and high-yield topics in the field of pediatric pulmonology that are up to date, comprehensive and pertinent to the practice of pediatric pulmonology.  

Goals

  1. To provide a list of noteworthy and relevant pediatric pulmonary publications that will enhance the clinical care provided by trainees.
  2. To provide a central location for pediatric pulmonary articles for the incoming and established pediatric pulmonary fellow.
  3. To provide a repository for recent publications, guidelines, and sentinel articles surrounding key topics of pediatric pulmonary medicine.
  4. To highlight areas of health disparities in pediatric pulmonary medicine as a basis for awareness and improvement as a pediatric pulmonary society.

Annual maintenance of the pediatric reading list

To collaborate with an expert panel of pediatric pulmonologists and a reading list subcommittee in the pediatric assembly:

Role of the expert panel and subcommittee: To update the ATS Pediatric Reading list annually with:

  • Clinical studies that are shaping the debate over the current standard of care.
  • Landmark articles of historical significance.
  • A select number of highly influential practice guidelines.
  • Articles highlighting health disparities in pediatric pulmonary practice.

A. GERD

Groundbreaking/New Articles

Guidelines

  1. Chang AB, Oppenheimer JJ, Kahrilas PJ, Kantar A, Rubin BK, Weinberger M, Irwin RS; CHEST Expert Cough Panel. Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report. Chest. 2019 Jul;156(1):131-140. doi: 10.1016/j.chest.2019.03.035. Epub 2019 Apr 16. PMID: 31002783; PMCID: PMC6859246.
  2. de Benedictis FM, Bush A. Respiratory manifestations of gastro-oesophageal reflux in children. Arch Dis Child. 2018 Mar;103(3):292-296. doi: 10.1136/archdischild-2017-312890. Epub 2017 Sep 7. PMID: 28882881.
  3. Dziekiewicz M, Marczak H, Banasiuk M, Aksionchyk M, Krenke K, Banaszkiewicz A. Characteristics of gastroesophageal reflux disease in children with interstitial lung disease. Pediatr Pulmonol. 2023 Jan;58(1):171-177. doi: 10.1002/ppul.26176. Epub 2022 Oct 11. PMID: 36196557.
  4. Sentinel Articles
  5. Boesch RP, Balakrishnan K, Acra S, Benscoter DT, Cofer SA, Collaco JM, Dahl JP, Daines CL, DeAlarcon A, DeBoer EM, Deterding RR, Friedlander JA, Gold BD, Grothe RM, Hart CK, Kazachkov M, Lefton-Greif MA, Miller CK, Moore PE, Pentiuk S, Peterson-Carmichael S, Piccione J, Prager JD, Putnam PE, Rosen R, Rutter MJ, Ryan MJ, Skinner ML, Torres-Silva C, Wootten CT, Zur KB, Cotton RT, Wood RE. Structure and Functions of Pediatric Aerodigestive Programs: A Consensus Statement. Pediatrics. 2018 Mar;141(3):e20171701. Doi: 10.1542/peds.2017-1701. Epub 2018 Feb 7. PMID: 29437862.
  6. Calabrese F, Rizzo S, Giacometti C, Panizzolo C, Turato G, Snijders D, Lunardi F, Vadori M, Valente M, Saetta M, Barbato A. High viral frequency in children with gastroesophageal reflux-related chronic respiratory disorders. Pediatr Pulmonol. 2008 Jul;43(7):690-6. doi: 10.1002/ppul.20841. PMID: 18500731.

Health Disparities.

  • Mahdavinia M, Bilaver LA, Fox S, Pappalardo AA, Andy-Nweye AB, Sharma HP, Assa'ad AH, Gupta RS, Tobin MC; FORWARD team. Racial disparity in treatment of gastroesophageal reflux disease in children with food allergy. J Allergy Clin Immunol Pract. 2022 Jan;10(1):339-342.e2. doi: 10.1016/j.jaip.2021.10.014. Epub 2021 Oct 19. PMID: 34678499; PMCID: PMC8748421.

 

B. Dysphagia

Groundbreaking/New Articles

Guidelines

Sentinel Articles

  1. Roden DF, Altman KW. Causes of dysphagia among different age groups: a systematic review of the literature. Otolaryngol Clin North Am. 2013 Dec;46(6):965-87. doi: 10.1016/j.otc.2013.08.008. Epub 2013 Oct 12. PMID: 24262954.
  2. Tutor JD, Gosa MM. Dysphagia and aspiration in children. Pediatr Pulmonol. 2012 Apr;47(4):321-37. doi: 10.1002/ppul.21576. Epub 2011 Oct 18. PMID: 22009835.
  3. Weir KA, McMahon S, Taylor S, Chang AB. Oropharyngeal aspiration and silent aspiration in children. Chest. 2011 Sep;140(3):589-597. doi: 10.1378/chest.10-1618. Epub 2011 Mar 24. PMID: 21436244.
  4. Weir K, McMahon S, Barry L, Masters IB, Chang AB. Clinical signs and symptoms of oropharyngeal aspiration and dysphagia in children. Eur Respir J. 2009 Mar;33(3):604-11. doi: 10.1183/09031936.00090308. Epub 2008 Nov 14. PMID: 19010985.

Health Disparities.

 

C. Chronic Cough

Groundbreaking/New Articles

Guidelines

  1. Chang AB, Oppenheimer JJ, Irwin RS; CHEST Expert Cough Panel. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2020 Jul;158(1):303-329. doi: 10.1016/j.chest.2020.01.042. Epub 2020 Mar 14. PMID: 32179109.

Sentinel Articles

  1. Chang AB, Oppenheimer JJ, Weinberger M, Grant CC, Rubin BK, Irwin RS; CHEST Expert Cough Panel. Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report. Chest. 2017 Sep;152(3):607-617. doi: 10.1016/j.chest.2017.06.006. Epub 2017 Jun 21. PMID: 28645463; PMCID: PMC6026225.
  2. Chang AB, Oppenheimer JJ, Weinberger M, Rubin BK, Irwin RS. Children With Chronic Wet or Productive Cough--Treatment and Investigations: A Systematic Review. Chest. 2016 Jan;149(1):120-42. doi: 10.1378/chest.15-2065. Epub 2016 Jan 6. PMID: 26757284.
  3. Anne B. Chang, Peter P. Van Asperen, MD, Nicholas Glasgow, MD, Colin F. Robertson, MD, Craig M. Mellis, MD, I. Brent Masters, PhD, Louis I. Landau, MD, Laurel Teoh, MD, Irene Tjhung, MD, Helen L. Petsky, PhD, Peter S. Morris, PhD. Children With Chronic Cough. Chest. March 2015.

Health Disparities.

Groundbreaking/New Articles

  1. Ghimire, J. J., K. R. Jat, J. Sankar, R. Lodha, V. K. Iyer, H. Gautam, S. Sood, and S. K. Kabra. 2022. "Azithromycin for Poorly Controlled Asthma in Children: A Randomized Controlled Trial." Chest 161, no. 6 (Jun): 1456-1464. https://dx.doi.org/10.1016/j.chest.2022.02.025.
  2. Brusselle, G. G., and G. H. Koppelman. 2022. "Biologic Therapies for Severe Asthma." N Engl J Med 386, no. 2 (Jan 13): 157-171.

Guidelines

  1. Cloutier, M. M., A. P. Baptist, K. V. Blake, E. G. Brooks, T. Bryant-Stephens, E. DiMango, A. E. Dixon, K. S. Elward, T. Hartert, J. A. Krishnan, R. F. Lemanske, D. R. Ouellette, W. D. Pace, M. Schatz, N. S. Skolnik, J. W. Stout, S. J. Teach, C. A. Umscheid, C. G. Walsh, and L.ng Expert Panel Working Group of the National Heart, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC). 2020. "2020 Focused Updates to the Asthma Management Guidelines: A report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group." J Allergy Clin Immunol 146, no. 6 (Dec): 1217-1270
  2. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention.". 2023. 2023.

Sentinel Articles

  1. Sobieraj, D. M., E. R. Weeda, E. Nguyen, C. I. Coleman, C. M. White, S. C. Lazarus, K. V. Blake, J. E. Lang, and W. L. Baker. 2018. "Association of Inhaled Corticosteroids and Long-Acting Β-Agonists as Controller and Quick Relief Therapy with Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-Analysis." JAMA 319, no. 14 (Apr 10): 1485-1496.
  2. Martinez, F. D., A. L. Wright, L. M. Taussig, C. J. Holberg, M. Halonen, and W. J. Morgan. 1995. "Asthma and Wheezing in the First Six Years of Life. The Group Health Medical Associates." N Engl J Med 332, no. 3 (Jan 19): 133-8.

Health Disparities.

  1. Baptist, A. P., A. J. Apter, P. J. Gergen, and B. L. Jones. 2023. "Reducing Health Disparities in Asthma: How Can Progress Be Made." J Allergy Clin Immunol Pract 11, no. 3 (Mar): 737-745.
  2. Gaffney, A. W., L. Hawks, D. Bor, A. C. White, S. Woolhandler, D. McCormick, and D. U. Himmelstein. 2021. "National Trends and Disparities in Health Care Access and Coverage among Adults with Asthma and Copd: 1997-2018." Chest 159, no. 6 (Jun): 2173-2182.

Groundbreaking/New Articles

  1. Kobbernagel, H. E., F. F. Buchvald, E. G. Haarman, C. Casaulta, S. A. Collins, C. Hogg, C. E. Kuehni, J. S. Lucas, C. E. Moser, A. L. Quittner, J. Raidt, S. Rosthøj, A. L. Sørensen, K. Thomsen, C. Werner, H. Omran, and K. G. Nielsen. 2020. "Efficacy and Safety of Azithromycin Maintenance Therapy in Primary Ciliary Dyskinesia (Bestcilia): A Multicentre, Double-Blind, Randomised, Placebo-Controlled Phase 3 Trial." Lancet Respir Med 8, no. 5 (May): 493-505.
  2. Shoemark, A., H. Griffin, G. Wheway, C. Hogg, J. S. Lucas, C. Camps, J. Taylor, M. Carroll, M. R. Loebinger, J. D. Chalmers, D. Morris-Rosendahl, H. M. Mitchison, A. De Soyza, D. Brown, J. C. Ambrose, P. Arumugam, R. Bevers, M. Bleda, F. Boardman-Pretty, C. R. Boustred, H. Brittain, M. J. Caulfield, G. C. Chan, T. Fowler, A. Giess, A. Hamblin, S. Henderson, T. J. P. Hubbard, R. Jackson, L. J. Jones, D. Kasperaviciute, M. Kayikci, A. Kousathanas, L. Lahnstein, S. E. A. Leigh, I. U. S. Leong, F. J. Lopez, F. Maleady-Crowe, M. McEntagart, F. Minneci, L. Moutsianas, M. Mueller, N. Murugaesu, A. C. Need, P. O'Donovan, C. A. Odhams, C. Patch, D. Perez-Gil, M. B. Pereira, J. Pullinger, T. Rahim, A. Rendon, T. Rogers, K. Savage, K. Sawant, R. H. Scott, A. Siddiq, A. Sieghart, S. C. Smith, A. Sosinsky, A. Stuckey, M. Tanguy, A. L. Taylor Tavares, E. R. A. Thomas, S. R. Thompson, A. Tucci, M. J. Welland, E. Williams, K. Witkowska, S. M. Wood, Genomics England Research Consortium, and Genomics England Research Consortium:. 2022. "Genome Sequencing Reveals Underdiagnosis of Primary Ciliary Dyskinesia in Bronchiectasis." Eur Respir J 60, no. 5 (Nov).
  3. Ringshausen, F. C., A. J. Shapiro, K. G. Nielsen, H. Mazurek, M. Pifferi, K. H. Donn, M. M. van der Eerden, M. R. Loebinger, M. A. Zariwala, M. W. Leigh, M. R. Knowles, T. W. Ferkol, and CLEAN-PCD investigators and study team. 2024. "Safety and Efficacy of the Epithelial Sodium Channel Blocker Idrevloride in People with Primary Ciliary Dyskinesia (Clean-Pcd): A Multinational, Phase 2, Randomised, Double-Blind, Placebo-Controlled Crossover Trial." Lancet Respir Med 12, no. 1 (Jan): 21-33.

Guidelines

  1. Chang, A. B., R. Fortescue, K. Grimwood, E. Alexopoulou, L. Bell, J. Boyd, A. Bush, J. D. Chalmers, A. T. Hill, B. Karadag, F. Midulla, G. B. McCallum, Z. Powell, D. Snijders, W. J. Song, T. Tonia, C. Wilson, A. Zacharasiewicz, and A. Kantar. 2021. "European Respiratory Society Guidelines for the Management of Children and Adolescents with Bronchiectasis." Eur Respir J 58, no. 2 (Aug).
  2. Shapiro, A. J., S. D. Davis, D. Polineni, M. Manion, M. Rosenfeld, S. D. Dell, M. A. Chilvers, T. W. Ferkol, M. A. Zariwala, S. D. Sagel, M. Josephson, L. Morgan, O. Yilmaz, K. N. Olivier, C. Milla, J. E. Pittman, M. L. A. Daniels, M. H. Jones, I. A. Janahi, S. M. Ware, S. J. Daniel, M. L. Cooper, L. M. Nogee, B. Anton, T. Eastvold, L. Ehrne, E. Guadagno, M. R. Knowles, M. W. Leigh, V. Lavergne, and Pediatrics American Thoracic Society Assembly on. 2018. "Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline." Am J Respir Crit Care Med 197, no. 12 (Jun 15): e24-e39.
  3. Lucas, J. S., A. Barbato, S. A. Collins, M. Goutaki, L. Behan, D. Caudri, S. Dell, E. Eber, E. Escudier, R. A. Hirst, C. Hogg, M. Jorissen, P. Latzin, M. Legendre, M. W. Leigh, F. Midulla, K. G. Nielsen, H. Omran, J. F. Papon, P. Pohunek, B. Redfern, D. Rigau, B. Rindlisbacher, F. Santamaria, A. Shoemark, D. Snijders, T. Tonia, A. Titieni, W. T. Walker, C. Werner, A. Bush, and C. E. Kuehni. 2017. "European Respiratory Society Guidelines for the Diagnosis of Primary Ciliary Dyskinesia." Eur Respir J 49, no. 1 (Jan).

Sentinel Articles

  1. Bush, A., and R. A. Floto. 2019. "Pathophysiology, Causes and Genetics of Paediatric and Adult Bronchiectasis." Respirology 24, no. 11 (Nov): 1053-1062.
  2. Flume, P. A., J. D. Chalmers, and K. N. Olivier. 2018. "Advances in Bronchiectasis: Endotyping, Genetics, Microbiome, and Disease Heterogeneity." Lancet 392, no. 10150 (Sep 08): 880-890.

Health Disparities.

  1. Hannah, W. B., B. A. Seifert, R. Truty, M. A. Zariwala, K. Ameel, Y. Zhao, K. Nykamp, and B. Gaston. 2022. "The Global Prevalence and Ethnic Heterogeneity of Primary Ciliary Dyskinesia Gene Variants: A Genetic Database Analysis." Lancet Respir Med 10, no. 5 (May): 459-468.
  2. Hunter-Schouela, J., M. T. Geraghty, R. A. Hegele, D. A. Dyment, D. St Pierre, J. Richer, H. Sheffield, M. A. Zariwala, M. R. Knowles, A. Lehman, S. Dell, A. J. Shapiro, and T. A. Kovesi. 2023. "First Reports of Primary Ciliary Dyskinesia Caused by a Shared Dnah11 Allele in Canadian Inuit." Pediatr Pulmonol 58, no. 7 (Jul): 1942-1949.

Groundbreaking/New Articles

  1. Cristea AL et al. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7
  2. Hay S et al. Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta-analysis. Cochrane Database Syst Rev. 2023 Aug 31;8(8):CD013730
  3. Sweet DG et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update. Neonatology. 2023;120(1):3-23
  4. Gilfillan M et al. Diagnosis and management of bronchopulmonary dysplasia. BMJ. 2021 Oct 20;375:n1974
  5. Jensen EA et al. The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants. An Evidence-based Approach. Am J Respir Crit Care Med. 2019 Sep 15;200(6):751-759

Guidelines

  1. Abman S et al. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017 Feb;181:12-28.e1

Sentinel Articles

  1. Baraldi E et al. Chronic Lung Disease after Premature Birth. N Engl J Med. 2007 Nov 8;357(19):1946-55
  2. Jobe A et al. Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2001 Jun;163(7):1723-9
  3. Baker CD et al. Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia. Pediatr Allergy Immunol Pulmonol 2014 Mar 1;27(1):8-16
  4. Doyle LW et al and the DART Study Investigators. Low-Dose Dexamethasone Facilitates Extubation Among Chronically Ventilator-Dependent Infants: A Multicenter, International, Randomized, Controlled Trial. Pediatrics 2006. Jan;117(1):75-83

Health Disparities.

  1. Lewis TR et al. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. Bronchopulmonary Dysplasia Collaborative. JAMA Pediatr. 2022 Sep 1;176(9):852-859
  2. Kelchtermans J et al. Ambient Air Pollution and Outpatient Morbidities in Bronchopulmonary Dysplasia. Ann Am Thorac Soc. 2023 Sep 13

Groundbreaking/New Articles

https://www.thoracic.org/members/assemblies/assemblies/peds/pediatric-flexible-bronchoscopy-library/

Guidelines

  1. Davis, E. Eber, C. Huddleston, T. Kilbaugh, G. Kurland, F. Midulla, D. Molter, G. S. Montgomery, G. Retsch-Bogart, M. J. Rutter, G. Visner, S. A. Walczak, T. W. Ferkol, P. H. Michelson, and American Thoracic Society Ad Hoc Committee on Flexible Airway Endoscopy in Children. 2015. "Official American Thoracic Society Technical Standards: Flexible Airway Endoscopy in Children." Am J Respir Crit Care Med 191, no. 9 (May 01): 1066-80.
  2. Goussard, P., E. Eber, S. Venkatakrishna, J. Janson, P. Schubert, and S. Andronikou. 2023. "Bronchoscopy Findings in Children with Congenital Lung and Lower Airway Abnormalities." Paediatr Respir Rev  (Oct 30).

Sentinel Articles

Health Disparities.

Groundbreaking/New Articles

  1. Gallant JN et al. Neonatal Laryngotracheal Anomalies. AAP Neo Reviews. Vol. 23 No. 9 September 2022 e613
  2. Wagner R et al. Basic and translational science advances in congenital diaphragmatic hernia. Semin Perinatol. 2020 Feb;44(1):151170

Guidelines

  1. Baird R et al. Congenital lung malformations: Informing best practice. Seminars in Paediatric Surgery. Volume 23, Issue 5, October 2014, Pages 270-277

Sentinel Articles

  1. Masters IB. "Congenital airway lesions and lung disease." Pediatr Clin North Am. 2009 Feb;56(1):227-42
  2. Bush A. Congenital Lung Disease: A Plea for Clear Thinking and Clear Nomenclature. Pediatric Pulmonology 32:328±337 (2001)
  3. Hysinger EB et al. Paediatric Tracheomalacia. Pediatric Respiratory Reviews 17 (2016) 9-15
  4. Seear M et al. A review of congenital lung malformations with a simplified classification system for clinical and research use. Paediatr Surg Int (2017) 33:657–664
  5. Zani A et al. Congenital diaphragmatic hernia. Nat Rev Dis Primers. 2022 Jun 1;8(1):37

Health Disparities.

  1. Sferra AR et al. Racial and Ethnic Disparities in Outcomes Among Newborns with Congenital Diaphragmatic Hernia. JAMA Netw Open. 2023 Apr 3;6(4):e2310800

Groundbreaking/New Articles

  1. Mielus M, Sands D, Woynarowski M. Improving nutrition in cystic fibrosis: A systematic literature review. Nutrition. 2022 Oct;102:111725. doi: 10.1016/j.nut.2022.111725. Epub 2022 May 6. PMID: 35816813.
  2. DeFilippo EMM, Talwalkar JS, Harris ZM, Butcher J, Nasr SZ. Transitions of Care in Cystic Fibrosis. Clin Chest Med. 2022 Dec;43(4):757-771. doi: 10.1016/j.ccm.2022.06.016. PMID: 36344079.

Guidelines

  1. Farrell PM, White TB, Ren CL, Hempstead SE, Accurso F, Derichs N, Howenstine M, McColley SA, Rock M, Rosenfeld M, Sermet-Gaudelus I, Southern KW, Marshall BC, Sosnay PR. Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation. J Pediatr. 2017 Feb;181S:S4-S15.e1. doi: 10.1016/j.jpeds.2016.09.064. Erratum in: J Pediatr. 2017 May;184:243. PMID: 28129811.
  2. Daley CL, Iaccarino JM, Lange C, Cambau E, Wallace RJ Jr, Andrejak C, Böttger EC, Brozek J, Griffith DE, Guglielmetti L, Huitt GA, Knight SL, Leitman P, Marras TK, Olivier KN, Santin M, Stout JE, Tortoli E, van Ingen J, Wagner D, Winthrop KL. Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline. Eur Respir J. 2020 Jul 7;56(1):2000535. doi: 10.1183/13993003.00535-2020. PMID: 32636299; PMCID: PMC8375621.
  3. Ramos KJ, Smith PJ, McKone EF, Pilewski JM, Lucy A, Hempstead SE, Tallarico E, Faro A, Rosenbluth DB, Gray AL, Dunitz JM; CF Lung Transplant Referral Guidelines Committee. Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines. J Cyst Fibros. 2019 May;18(3):321-333. doi: 10.1016/j.jcf.2019.03.002. Epub 2019 Mar 27. PMID: 30926322; PMCID: PMC6545264.

Sentinel Articles

  1. Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Epub 2019 Oct 31. PMID: 31697873; PMCID: PMC7282384.
  2. Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, Dřevínek P, Griese M, McKone EF, Wainwright CE, Konstan MW, Moss R, Ratjen F, Sermet-Gaudelus I, Rowe SM, Dong Q, Rodriguez S, Yen K, Ordoñez C, Elborn JS; VX08-770-102 Study Group. A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med. 2011 Nov 3;365(18):1663-72. doi: 10.1056/NEJMoa1105185. PMID: 22047557; PMCID: PMC3230303.
  3. Leung DH, Heltshe SL, Borowitz D, Gelfond D, Kloster M, Heubi JE, Stalvey M, Ramsey BW; Baby Observational and Nutrition Study (BONUS) Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network. Effects of Diagnosis by Newborn Screening for Cystic Fibrosis on Weight and Length in the First Year of Life. JAMA Pediatr. 2017 Jun 1;171(6):546-554. doi: 10.1001/jamapediatrics.2017.0206. PMID: 28437538; PMCID: PMC5731827.
  4. Ren CL, Borowitz DS, Gonska T, Howenstine MS, Levy H, Massie J, Milla C, Munck A, Southern KW. Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome and Cystic Fibrosis Screen Positive, Inconclusive Diagnosis. J Pediatr. 2017 Feb;181S:S45-S51.e1. doi: 10.1016/j.jpeds.2016.09.066. PMID: 28129812.
  5. Stoltz DA, Meyerholz DK, Welsh MJ. Origins of cystic fibrosis lung disease. N Engl J Med. 2015 Jan 22;372(4):351-62. doi: 10.1056/NEJMra1300109. PMID: 25607428; PMCID: PMC4916857.

Health Disparities.

  1. Palla JB. Disparities and therapeutic advances in cystic fibrosis. Pediatr Pulmonol. 2023 May 3. doi: 10.1002/ppul.26445. Epub ahead of print. PMID: 37133222.
  2. McGarry ME, Williams WA 2nd, McColley SA. The demographics of adverse outcomes in cystic fibrosis. Pediatr Pulmonol. 2019 Nov;54 Suppl 3(Suppl 3):S74-S83. doi: 10.1002/ppul.24434. PMID: 31715087; PMCID: PMC6857719.

Groundbreaking/New Articles

  1. Ferraro VA, Zanconato S, Zamunaro A, Carraro S. Children's Interstitial and Diffuse Lung Diseases (ChILD) in 2020. Children (Basel). 2020 Dec 9;7(12):280. doi: 10.3390/children7120280. PMID: 33316882; PMCID: PMC7763071.
  2. Nogee LM. Genetic causes of surfactant protein abnormalities. Curr Opin Pediatr. 2019 Jun;31(3):330-339. doi: 10.1097/MOP.0000000000000751. PMID: 31090574; PMCID: PMC6530488.
  3. Deutsch GH, Young LR. Lung biopsy in the diagnosis and management of chILD. Pediatr Pulmonol. 2023 May 8. doi: 10.1002/ppul.26454. Epub ahead of print. PMID: 37154500.
  4. Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR. Neuroendocrine Cell Hyperplasia of Infancy. Clinical Score and Comorbidities. Ann Am Thorac Soc. 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152; PMCID: PMC7258416.
  5. Nevel RJ, Garnett ET, Schaudies DA, Young LR. Growth trajectories and oxygen use in neuroendocrine cell hyperplasia of infancy. Pediatr Pulmonol. 2018 May;53(5):656-663. doi: 10.1002/ppul.23958. Epub 2018 Feb 2. PMID: 29393588; PMCID: PMC5903936.

Guidelines

  1. Semple T, Winant AJ, Lee EY. Childhood Interstitial Lung Disease: Imaging Guidelines and Recommendations. Radiol Clin North Am. 2022 Jan;60(1):83-111. doi: 10.1016/j.rcl.2021.08.009. PMID: 34836568.

Sentinel Articles

  1. Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD, Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston C; Pathology Cooperative Group; Albright EA, Askin FB, Baker P, Chou PM, Cool CM, Coventry SC, Cutz E, Davis MM, Dishop MK, Galambos C, Patterson K, Travis WD, Wert SE, White FV; ChILD Research Co-operative. Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1120-8. doi: 10.1164/rccm.200703-393OC. Epub 2007 Sep 20. PMID: 17885266; PMCID: PMC2176101.
  2. Brody AS, Guillerman RP, Hay TC, Wagner BD, Young LR, Deutsch GH, Fan LL, Deterding RR. Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT. AJR Am J Roentgenol. 2010 Jan;194(1):238-44. doi: 10.2214/AJR.09.3385. PMID: 20028928; PMCID: PMC3785715.

Health Disparities.

  1. Deterding RR, DeBoer EM, Cidon MJ, Robinson TE, Warburton D, Deutsch GH, Young LR. Approaching Clinical Trials in Childhood Interstitial Lung Disease and Pediatric Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 Nov 15;200(10):1219-1227. doi: 10.1164/rccm.201903-0544CI. PMID: 31322415; PMCID: PMC6945798.

Groundbreaking/New Articles

  1. Fitch T et al. Pulmonary Complications After Pediatric Stem Cell Transplant. Front Oncol. 2021;11:755878
  2. Fraebel J et al. Noninfectious Pulmonary Complications after Hematopoietic Stem Cell Transplantation. 2023 Feb;29(2):82-93
  3. Shanthikumar S et al. Pulmonary surveillance in pediatric hematopoietic stem cell transplant: A multinational multidisciplinary survey. Cancer Rep (Hoboken). 2022;5(5):e1501.

Guidelines

  1. Meyer KC et al; ISHLT/ATS/ERS BOS Task Force Committee; ISHLT/ATS/ERS BOS Task Force Committee. An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. Eur Respir J. 2014 Dec;44(6):1479-503
  2. Cooke KR et al. The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017;23(2):211-34.

Sentinel Articles

  1. Duncan CN et al. Bronchiolitis obliterans following pediatric allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008;41(11):971-5
  2. Cheng GS et al. Lung Function Trajectory in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplant. Ann Am Thorac Soc. 2016;13(11):1932-9
  3. Chellapandian D et al. Bronchoalveolar lavage and lung biopsy in patients with cancer and hematopoietic stem-cell transplantation recipients: a systematic review and meta-analysis. J Clin Oncol. 2015;33(5):501-9.
  4. Meignin V et al. Lung histopathology of non-infectious pulmonary complications after allogeneic haematopoietic stem cell transplantation. Histopathology. 2018;73(5):832-42

Health Disparities.

  1. Landry I. Racial disparities in hematopoietic stem cell transplant: a systematic review of the literature. Stem Cell Investig. 2021 Dec 14:8:24

Groundbreaking/New Articles

  1. Strauss KA, Farrar MA, Muntoni F, et al. Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial. Nat Med. 2022;28(7):1381-1389. doi:10.1038/s41591-022-01866-4

Guidelines

  1. Birnkrant DJ, Bushby K, Bann CM, et al. Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management. Lancet Neurol. 2018;17(4):347-361. doi:10.1016/S1474-4422(18)30025-5
  2. Finkel RS, Mercuri E, Meyer OH, et al. Diagnosis and management of spinal muscular atrophy: Part 2: Pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics. Neuromuscul Disord. 2018;28(3):197-207. doi:10.1016/j.nmd.2017.11.004
  3. Birnkrant DJ, Panitch HB, Benditt JO, et al. American College of Chest Physicians consensus statement on the respiratory and related management of patients with Duchenne muscular dystrophy undergoing anesthesia or sedation. Chest. 2007;132(6):1977-1986. doi:10.1378/chest.07-0458

Sentinel Articles

  1. Mendell JR, Moxley RT, Griggs RC, et al. Randomized, double-blind six-month trial of prednisone in Duchenne's muscular dystrophy. N Engl J Med. 1989;320(24):1592-1597. doi:10.1056/NEJM198906153202405

Health Disparities.

  1. Mann JR, Zhang Y, McDermott S, et al. Racial and Ethnic Differences in Timing of Diagnosis and Clinical Services Received in Duchenne Muscular Dystrophy. Neuroepidemiology. 2023;57(2):90-99. doi:10.1159/000528962

Groundbreaking/New Articles

  1. Rodriguez Lara F, Carnino JM, Cohen MB, Levi JR. Advances in the Use of Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Persistent Obstructive Sleep Apnea-A Systematic Review. Ann Otol Rhinol Laryngol. 2024;133(3):317-324. doi:10.1177/00034894231216287

Guidelines

  1. Ehsan Z, Ishman SL, Soghier I, et al. Management of Persistent, Post-adenotonsillectomy Obstructive Sleep Apnea in Children: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2024;209(3):248-261. doi:10.1164/rccm.202310-1857ST
  2. Sawnani H. Sleep disordered breathing in Duchenne muscular dystrophy. Paediatr Respir Rev. 2019;30:2-8. doi:10.1016/j.prrv.2018.07.003

Sentinel Articles

  1. Marcus CL, Moore RH, Rosen CL, et al. A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med. 2013;368(25):2366-2376. doi:10.1056/NEJMoa1215881

Health Disparities.

  1. Kou, Yann-Fuu, et al. “Tonsillectomy Outcomes among Children with Mental Health Disorders in the United States.” Otolaryngology-Head and Neck Surgery, vol. 162, no. 5, 2020, pp. 754–60, doi:10.1177/0194599820910115

Groundbreaking/New Articles

  1. Hoeper MM, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, McLaughlin VV, Preston IR, Souza R, Waxman AB, Grünig E, Kopeć G, Meyer G, Olsson KM, Rosenkranz S, Xu Y, Miller B, Fowler M, Butler J, Koglin J, de Oliveira Pena J, Humbert M; STELLAR Trial Investigators. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2023 Apr 20;388(16):1478-1490. doi: 10.1056/NEJMoa2213558. Epub 2023 Mar 6. PMID: 36877098.
  2. Ploegstra MJ, Ivy DD, Beghetti M, Bonnet D, Alehan D, Ablonczy L, Mattos S, Bowers D, Humpl T, Berger RMF; TOPP Investigators. Long-term outcome of children with newly diagnosed pulmonary arterial hypertension: results from the global TOPP registry. Eur Heart J Qual Care Clin Outcomes. 2024 Jan 12;10(1):66-76. doi: 10.1093/ehjqcco/qcad020. PMID: 36972621; PMCID: PMC10785586.
  3. Arjaans S, Fries MWF, Schoots MH, Schilte CFM, Roofthooft MTR, Vrijlandt EJLE, Bos AF, Kooi EMW, Berger RMF. Clinical Significance of Early Pulmonary Hypertension in Preterm Infants. J Pediatr. 2022 Dec;251:74-81.e3. doi: 10.1016/j.jpeds.2022.07.039. Epub 2022 Aug 4. PMID: 35934129.
  4. Hansmann G, Meinel K, Bukova M, et al. Selexipag for the treatment of children with pulmonary arterial hypertension: First multicenter experience in drug safety and efficacy. J Heart Lung Transplant. 2020;39(7):695-706. doi:10.1016/j.healun.2020.03.029

Guidelines

  1. Humbert M, Kovacs G, Hoeper MM, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension [published correction appears in Eur Heart J. 2023 Apr 17;44(15):1312]. Eur Heart J. 2022;43(38):3618-3731. doi:10.1093/eurheartj/ehac237
  2. Abman SH, Hansmann G, Archer SL, et al. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society [published correction appears in Circulation. 2016 Jan 26;133(4):e368]. Circulation. 2015;132(21):2037-2099. doi:10.1161/CIR.0000000000000329
  3. Sullivan RT, Raj JU, Austin ED. Recent Advances in Pediatric Pulmonary Hypertension: Implications for Diagnosis and Treatment. Clin Ther. 2023;45(9):901-912. doi:10.1016/j.clinthera.2023.07.001
  4. Lammers AE, Adatia I, Cerro MJ, et al. Functional classification of pulmonary hypertension in children: Report from the PVRI pediatric taskforce, Panama 2011. Pulm Circ. 2011;1(2):280-285. doi:10.4103/2045-8932.83445

Sentinel Articles

  1. Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Raj JU, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD; Pediatric Pulmonary Hypertension Network. Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry. Eur Respir J. 2021 Dec 31;59(1):2003337. doi: 10.1183/13993003.03337-2020. PMID: 34140292; PMCID: PMC10335325.
  2. Barst RJ, Ivy DD, Gaitan G, et al. A randomized, double-blind, placebo-controlled, dose-ranging study of oral sildenafil citrate in treatment-naive children with pulmonary arterial hypertension. Circulation. 2012;125(2):324-334. doi:10.1161/CIRCULATIONAHA.110.016667
  3. Barst RJ, Beghetti M, Pulido T, et al. STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension. Circulation. 2014;129(19):1914-1923. doi:10.1161/CIRCULATIONAHA.113.005698
  4. Takatsuki S, Rosenzweig EB, Zuckerman W, Brady D, Calderbank M, Ivy DD. Clinical safety, pharmacokinetics, and efficacy of ambrisentan therapy in children with pulmonary arterial hypertension. Pediatr Pulmonol. 2013;48(1):27-34. doi:10.1002/ppul.22555

Health Disparities.

  1. Ong MS, Abman S, Austin ED, et al. Racial and Ethnic Differences in Pediatric Pulmonary Hypertension: An Analysis of the Pediatric Pulmonary Hypertension Network Registry. J Pediatr. 2019;211:63-71.e6. doi:10.1016/j.jpeds.2019.04.046