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HomeMembersAssemblies and SectionsSectionsGenetics and GenomicsJournal Club ▶ Genetic Risk Profiles Development for Precision Medicine of CardioPulmonary Traits: Part 1 & Part 2
Genetic Risk Profiles Development for Precision Medicine of CardioPulmonary Traits: Part 1 & Part 2

Title: Genetic Risk Profiles Development for Precision Medicine of CardioPulmonary Traits: Part 1

This is the first of a series of two Journal Clubs of which part 1 will feature two articles: “Genome-wide association study of general populations reveal a risk profile of 97 genetic variants associated with lung function” by Louise Wain and colleagues that appeared in the March 2017 issue of Nature Genetics and “Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations” by Amit Khera and colleagues that appeared in the September 2018 issue of Nature Genetics. We are fortunate to have a discussion of these papers and their role in improving our understanding of precision medicine gene profiles with the first authors as discussants.

Presented by:

Elizabeth C. Oelsner, MD, MPH, Herbert Irving Assistant Professor, Department of Internal Medicine, Columbia University College of Physicians & Surgeons

Ani W. Manichaikul, PhD, Assistant Professor, Public Health Sciences, Center for Public Health Genomics, University of Virginia School of Medicine.

The first authors of each paper will serve as discussants:

Louise V. Wain, PhD, Professor, Department of Health Sciences, University of Leicester

Amit V. Khera, MD, Instructor, Center for Genomic Medicine, Department of Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Cardiovascular Disease Initiative of the Broad Institute of Harvard and MIT

and one additional discussant:

Michael Cho, MD, MPH, Assistant Professor, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Co-Chair, American Thoracic Society Section on Genetics and Genomics


Title: Genetic Risk Profiles Development for Precision Medicine of CardioPulmonary Traits: Part 2

This is the second of a series of two Journal Clubs which will feature two high-impact articles which were just published this month: “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries” by Nick Shrine and colleagues and “Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations” by Phuwanat Sakornsakolpat and colleagues. Both were electronically published in Nature Genetics this month. We are fortunate to have a timely discussion of these papers and their role in improving our understanding of precision medicine gene profiles with the co-authors and senior authors as presenters and discussants

Presented by:

Nick Shrine, PhD, Senior Research Associate in Genetic Epidemiology, University of Leicester

Brian Hobbs, MD, MMSc, Instructor in Medicine, Harvard Medical School, Brigham and Women’s Hospital

The senior authors of each paper will serve as discussants:

Louise V. Wain, PhD, British Lung Foundation Chair of Respiratory Research, Department of Health Sciences, University of Leicester

Michael Cho, MD, MPH, Assistant Professor, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Co-Chair, American Thoracic Society Section on Genetics and Genomics

The webinar and discussion will be hosted by our moderator:

Victor E. Ortega, MD, PhD, Associate Professor, Section on Pulmonary, Critical Care, Allergic, and Immunologic Diseases, Center for Precision Medicine, Wake Forest School of Medicine